Thumbs Up For Methadone and BNX
Pharmacy News
August 2009
Buprenorphine-naloxone and methadone have received endorsement as the most effective opioid replacement therapies.
A paper published in the latest issue of the Medical Journal of Australia (MJA) confirmed that buprenorphine-naloxone (BNX) was less likely than buprenorphine alone to be injected by both opioid replacement therapy patients (ORT) and injecting drug users.
Meanwhile a new Cochrane review confirmed that methadone maintenance therapy (MMT) was more effective than "cold turkey" methods in treating heroin dependence.
The MJA study found that in the year after its introduction in Australia, BNX was injected less frequently and by fewer regular injecting drug users and ORT clients than buprenorphine, particularly when differences in the availability of medications were taken into account.
Some individuals did nonetheless regularly inject BNX.
BNX is a combination of a partial opioid agonist and an opioid antagonist for treating opioid dependence, which was specifically developed to limit injection.
"Given that BNX has not only overtaken market sales of buprenorphine, but is also generally available as takeaway medication (unlike buprenorphine), the deterrent effect of the combination product may be even greater than the comparisons in our study suggest," the study's authors wrote.
"This finding has important implications for public health, given the potential for severe consequences of buprenorphine injection."
The Cochrane reviewers looked at 11 studies and found that MMT retained patients in treatment and decreased heroin use better than treatments that did not use ORT such as detoxification, offer of drug-free rehabilitation, placebo medication and wait-list controls.
However, MMT did not have a statistically significant superior effect on mortality or criminal activity, the reviewers found.
Tuesday, 18 August 2009
Again ... Substitution Treatment More Effective than Abstinence Programs
Monday, 25 August 2008
Q & A: Kerry Wolf -Certified Methadone Advocate (USA)
Q and A: Dr. James Rowe - Lecturer at RMIT, School of Global Studies, Social Science and Planning
Q and A: Gino Vumbaca - Executive Director of the Australian National Council on Drugs
Q and A: Sandra Kanck - Former South Australian MLC. South Australia spokesperson for Families and Friends for Drug Law Reform (FFDLR)
Q and A: Tony Trimingham - Chief Executive Officer, Family Drug Support
Saturday, 16 August 2008
Prescription Heroin - Lifesaving Medication?
As the results from Canada and Britain’s heroin trials approach, findings.org.uk have written an article about the positive outcomes of prescription heroin. A little known fact is that in Britain, heroin can already be prescribed for addiction under certain circumstances. The reality though is that because of the US’s obsession with prohibition and the pressure from the International Narcotics Control Board (INCB), heroin is rarely prescribed anymore, if at all.
Here is an extract from that article.
Role Reversal
By Mike Aston & John Witton
finding.org.uk
Controversial, expensive, yet promising so much, interest is increasing in prescribing heroin to heroin addicts. It’s the drug field’s ultimate role reversal from killer drug to lifesaving medication. Just five studies hold the answers to whether it can work.
Led by government ministers frustrated at slow progress in the fight against serious drug problems, Britain is about to revive its acquaintance with heroin not as a drug of abuse, but as a treatment for drug abuse. Heroin prescribing has traditionally been the main distinguishing feature of what was seen as the “British system” for responding to heroin addiction. It rested on the unique legal leeway afforded doctors in Britain, until recently the only nation which allowed heroin (in its pharmaceutical form called diamorphine) to be prescribed for the treatment of addiction. Before 1968, any doctor could exercise this prerogative. Since then the treatment has been restricted to specialists who hold the requisite Home Office licence, nearly all of whom work in NHS drug dependence clinics.
At first the dominant response to the 1960s UK heroin outbreak, soon diamorphine prescribing waned to be replaced by injectable and then oral methadone. Of the 70 or more licensed doctors today, perhaps 50 prescribe diamorphine (almost entirely in injectable form) to just 450 patients. An increase in these numbers can be expected to flow from the commitment in the UK
Why consider diamorphine?
The “Why bother?” question is the main one diamorphine has to answer. After all, Britain has spent the last 30 years moving away from diamorphine and towards oral methadone, a treatment with substantial research backing and which benefits many thousands of patients. Only if there are substantial extra benefits compared to oral methadone might the extra costs and risks be justified. Even then there would remain the issue of whether injectable methadone might provide the same benefits yet permit a less drug-dominated lifestyle - injecting once rather than three times a day and less pronounced mood swings.
The potential advantages of diamorphine derive from its anticipated pulling power for heroin addicts, defined traditionally and legally in Britain as having an “overpowering desire” for the chemical. Those who find methadone unappealing or for whom it fails to curtail heroin use might be attracted and retained by diamorphine, extending the benefits of maintenance therapy - social stabilisation, risk and crime reduction, health improvements - to yet more patients.
The same pulling power is the source of diamorphine’s potential drawbacks. Once known to be an option, new patients who would have been satisfied with and done well on oral methadone may demand diamorphine. They may even deliberately fail on methadone to “qualify” for the drug. Once in diamorphine treatment, relatively safe, hassle-free and cash-free access to their drug of choice might prolong patients’ careers as addicts and as patients. Injectable diamorphine maintains the frequency of injecting with its associated risks. As in the 1960s, addicts may sell all or part of their diamorphine, spreading addiction and risking the purchasers’ lives, yet preventing this by requiring thrice daily attendance for supervised injection is costly and unpopular with patients.
Establishing the validity of these hopes and fears sets the agenda for this review.
Read the entire article:
http://findings.org.uk/count/downloads/download.php?file=Ashton_M_22.pdf
Saturday, 5 July 2008
Methadone Saves More Lives Than Abstinence / Detox.
People who are opiate dependent like heroin addicts, will die at a rate of 13 -1 compared to non addicts of the same age/sex. Mind blowing stuff. But there are still many out there who object to substitution treatment despite it being the single most effective treatment for opiate addiction. What would happen though if abstinence based treatment like detox was found to have a higher mortality rate than opioid maintenance treatment (OMT)?
The Boston University has recently released several reports that should make many anti-methadone proponents reassess their ignorant and often arrogant views. Not only do they indicate that methadone and buprenorphine save lives but choosing abstinence/detox over OMT increases the chance of patients dying. The anti Harm Minimisation stooges will undoubtedly still push their naive, ‘drug free’ ideology but the fact is, those on methadone or buprenorphine have a hugely reduced risk of being a mortality statistic.
Isn’t this the goal, to save lives? It’s becoming increasingly obvious that’s not the case for some of the so-called “Tough Love” advocates. Extremist, Salvation Army Major and INCB member, Brian Watters suggested that heroin addiction was a fate worse then death. He also said that addiction was a sin. For the record, Watters is also a DFA director, ex chairman of the Australian National Council on Drugs (ANCD) and one of the 12 members of the UN’s International Narcotics Control Board (INCB) which has come into major criticism for breaching human rights and being a stooge for US drug policy. Many opponents of methadone use Sweden as an example of a successful drug policy which includes a strong preference for abstinence based programs and severe restrictions on how long someone can stay on methadone. What they leave out is the high mortality rate in Sweden compared to countries that endorse methadone.
This report is very specific about what needs to be done to prevent harm—not just to reduce it or minimise it but to prevent it, with the ultimate aim of always making the individual drug free and not sentenced to a lifetime of methadone, which will probably take 46 years off your life expectancy, and not turned into a hag with their teeth falling out. If you think the mouth of a tobacco-smoking person is hideous, look at the mouth of a methadone user.
Bronwyn Bishop - Inquiry Chair: The impact of illicit drug use on families. The winnable war on drugs.
There are many who object to substitution treatment as being a ‘cop out’ for addicts or as a grand plan of industry ‘elitists’ who want full drug legalisation. The claims are varied from an ‘Orwellian addiction swap’ to ‘the federal government trades places with the street dealer, swapping heroin for methadone and feeding the addiction with taxpayer dollars’. Even politicians who have access to vast amounts of research either choose to ignore the evidence and lie to the public or are incapable of separating their personal views from facts. What is worse ... an elected official blatantly deceiving us or an elected official being so obviously clueless and incapable yet still left to manage important issues for us?
Do we want to follow the example of the many US OMT clinics that place restrictions on the period of treatment or set unrealistic dosage levels out of misconceived ideas on how OMT works? OMT was never meant to be a short term treatment but through a haze of Zero Tolerance claptrap, the guidelines have been misinterpreted by many health care providers. It seems logical to end OMT as quickly as possible because of the temptation to have a cured addict, free of physical addiction. Unfortunately, it’s not that simple and the usual consequences are the unnecessary deaths of addicts pushed into a dangerous treatment plan by ignorant and self righteous care providers.
Opioid Maintenance Therapy Saves Lives
http://www.bu.edu/aodhealth/issues/issue_may08/friedmann_gibson.html
Opioid-dependent patients are 13 times more likely to die than their age- and sex-matched peers in the general population. To examine predictors of long-term mortality, Australian researchers conducted a 10-year follow-up study of 405 heroin-dependent patients who had participated in a randomized trial comparing methadone and buprenorphine.
Overall mortality was 8.8 deaths per 1000 person-years of follow-up (0.66 during opioid maintenance treatment and 14.3 while out of treatment).
Each additional opioid maintenance treatment episode lasting more than 7 days decreased mortality by 28%.
Subjects who were using more heroin at baseline had a 12% lower mortality rate overall, likely because they spent more time in opioid maintenance treatment.
Comments:
Often overlooked in the controversy over opioid substitution therapy is the reality that opioid dependence has a high fatality rate. The current study highlights that opioid maintenance treatment saves lives. The selection of the treatment episode as greater than 7 days strongly suggests that opioid maintenance, not detoxification, reduces mortality. The time is right to promulgate opioid maintenance therapy with either buprenorphine or methadone as the standard-of-care, first-line treatment for opioid dependence.
Peter D. Friedmann, MD, MPH
Reference: Gibson A, Degenhardt L, Mattick RP, et al. Exposure to opioid maintenance treatment reduces long-term mortality. Addiction. 2008;103(3):462–468.
Death Before, During, and After Opioid Maintenance Treatment
http://www.bu.edu/aodhealth/issues/issue_apr08/samet_clausen.html
To what extent does opioid maintenance therapy (OMT) reduce mortality in patients with dependence? To answer this question, Norwegian researchers linked data from a national death registry to a national database of people who were on a waiting list for OMT, receiving OMT (predominantly methadone), or discontinued OMT. Researchers then compared the risk of death during treatment with the risk before and after treatment among 3789 patients. In some cases, data from the death registry were confirmed with death certificates and autopsy results.
Over 7 years, 213 patients died.
Seventy-nine percent of deaths in the waiting-list group, 27% of deaths in the treatment group, and 61% of deaths in the discontinued-treatment group were attributed to overdose.
Mortality risk (from overdose and other causes) was significantly lower in patients receiving treatment than in patients on the waiting list (relative risk [RR], 0.5; death rates of 1.4 versus 2.4 per 100 person years, respectively).
Risk was highest among men who discontinued treatment (RR, 1.8 compared with men on the waiting list).
Comments:
With impressive methodological rigor, these investigators provide further strong evidence that OMT lowers the risk of death. Because of the increasing cases of overdose death attributed to physician-prescribed methadone for pain and the potential negative public backlash towards this treatment, these data may play an important role in policy efforts that support the continued use of OMT to reduce mortality risk in people with opioid dependence.
Jeffrey A. Samet, MD, MA, MPH
Reference: Clausen T, Anchersen K, Waal H. Mortality prior to, during, and after opioid maintenance treatment (OMT): a national prospective cross-registry study. Drug Alcohol Depend. 2008;94(1-3):151-157.
Related Links:
What are the benefits of Methadone Maintenance Treatment
Advocates For Recovery Through Medicine
Ideological Influence in Addiction Treatment
Naltrexone Implant Data: Dangerous - MJA
Tuesday, 10 June 2008
Diary: Is My Pharmacist Committed?
I am guessing most methadone patients have had the frustrating experience of waiting in line for service only to be overlooked when a regular customer comes to the counter. I am also guessing that many methadone patients have found themselves at odds with the pharmacist on at least one occasion. If you happen to pick the wrong chemist, it can cause methadone patients much, unneeded grief which often erupts into an outburst of frustration and anger. The chemist gladly informs their 2nd rate customer that they are off the program. The ex customer has to then find another chemist, which is usually for the best in the long run.
That all changed for me when I switched to SROM ... well I thought it did. Not having to go to the special counter for methadone patients was a big bonus and I was treated as regular customer who was just receiving a normal prescription. So I thought at first.
My script is presented monthly and I pick up weekly. I had some extra medication at the start so I could come in a few days late if I was unable to get to the chemist on time. I usually pick up Thursday evenings for the following week but sometimes I would leave it until Friday or Saturday and I would just receive a week’s worth of medication. One day that all changed with a different pharmacist. The pharmacist decided that my weekly pick up started on the day I came in and since I was one day late, I would be short a day. She explained the script said “pickup dose every 7 days”. She knew it was a technicality and since my doctor was on holidays, she couldn’t ring him. I finally sorted it out with the owner and I agreed to come in every Thursday to keep it simple. My doctor also changed my script to say “weekly pickup” so I could come in any day within the week.
I stuck to the Thursday agreement but this week I was at a funeral and I forgot to pick up my dose. I came in the next morning as soon as the chemist opened but agian was told that my week now started on Friday instead of Thursday. I was furious and stormed out. I came back to point out the new script but the pharmacist just casually flopped over to the counter sucking on a lollipop and slapped the prescription down without saying a word. I showed her the new wording but she didn’t even respond. I was a customer for fuck’s sake but a junkie is a junkie and I wasn’t worthy of customer status.
I rang the owner but he couldn’t get his head around the days. He said that if i got my medication on Friday, next Thursday would only be 6 days. I said that shouldn’t matter as we had been through this before all I wanted was to pick up my meds on Thursdays like usual. He got mixed up with days and numbers and kept repeating the same illogical outcomes even though he agreed he was wrong only 30 seconds before. His final solution was come in on Thursday as normal and he will just give me 6 days worth to get it back in line. WTF? One mixed up chemist!
It was so simple. I have a one day buffer which means I have my last dose Thursday morning, pickup my script that night and start the next morning, Friday. I have the buffer because I take my dose before 7am so it kicks in by 9am otherwise I am in massive pain and start withdrawal. If I have to wait until the chemist opens at 9am, I am not getting my meds working until 11am-12pm.
I asked them to ring my doctor but somehow this was not an option anymore. Can you picture an insulin patient having to miss a day because they came in a day late? What about someone on medication for a heart attack? A day early is different but this is after the due date. Originally they stated that the script specifically said that medication was every 7 days but when I purposely had the script changed to clear this problem up it wasn’t the issue anymore. They conveniently changed their mind that this was the reason.
Funny enough, I used to come in late one or two days for the first few months and nothing was even mentioned, until I got the pharmacist from hell. Why was I treated with suspicion but they still wouldn’t ring my doctor? I was doing fine coming in every Thursday but one day I come in Friday morning and my medication gets pushed back a day. The pharmacist treated me like shit and this just would not happen with other customers.
I approached another chemist near by and they said they would be happy to treat me as a customer regardless of when I came in. As long as my script said “weekly pickup” and I didn’t come in earlier than the due day, it was up to me when I picked up my medication. I asked them to ring my doctor to make sure but they said it wasn’t necessary because they understood the logic of “weekly pickup”. I wonder what a customer of 10 years has to do to get treated like I was. It all came down to one junior pharmacist and the owner who couldn’t do the maths in his head. One phone call to my doctor would have cleared it all up.
Just as I was getting my life together, I get let down by my doctors and then the chemist. I have enough problems to deal with! It seems that addiction warrants others to put you through extra misery without consideration for being a person with needs and feelings. There are very few positive experiences being an addict with depression and it is extremely upsetting when your only relief, your medication is unnecessarily interfered with. It is easy to become cynical when it happens regularly whilst having the public consider you less than human as well.
Many methadone patients (including myself) have become loud and angry when obvious discrimination occurs and usually it results in punitive action which only inflames the patient even more. I’ve seen it dozens of times at pharmacies especially certain ones that seem to thrive on acting superior to the patient. No one can really understand until they have been through it and I don’t wish it on anyone. I have never heard one single methadone patient ever ask for anything more than being treated the same as everyone else. Is that too much to ask? ... and people wonder why there are relapses.
For more horror stories, visit A.T. Watchdog. If you think we have it bad in Australia, try the US.
Thursday, 1 May 2008
Diary: Some Clarification
Thursday, 3 April 2008
Oh McCain ... You've Done It Again
Reporter: “Should U.S. taxpayer money go to places like Africa to fund contraception to prevent AIDS?”McCain: “Well I think it’s a combination. The guy I really respect on this is Dr. Coburn. He believes – and I was just reading the thing he wrote– that you should do what you can to encourage abstinence where there is going to be sexual activity. Where that doesn’t succeed, than he thinks that we should employ contraceptives as well. But I agree with him that the first priority is on abstinence. I look to people like Dr. Coburn. I’m not very wise on it.”( McCain turns to take a question on Iraq, but a moment later looks back to the reporter who asked him about AIDS.)McCain: “I haven’t thought about it. Before I give you an answer, let me think about. Let me think about it a little bit because I never got a question about it before. I don’t know if I would use taxpayers’ money for it.”Q: “What about grants for sex education in the United States? Should they include instructions about using contraceptives? Or should it be Bush’s policy, which is just abstinence?”McCain: (Long pause) “Ahhh. I think I support the president’s policy.”Q: “So no contraception, no counseling on contraception. Just abstinence. Do you think contraceptives help stop the spread of HIV?”McCain: (Long pause) “You’ve stumped me.”Q: “I mean, I think you’d probably agree it probably does help stop it?”McCain: (Laughs) “Are we on the Straight Talk express? I’m not informed enough on it. Let me find out. You know, I’m sure I’ve taken a position on it on the past. I have to find out what my position was. Brian(press secretary), would you find out what my position is on contraception – I’m sure I’m opposed to government spending on it, I’m sure I support the president’s policies on it.”Q: “But you would agree that condoms do stop the spread of sexually transmitted diseases. Would you say: ‘No, we’re not going to distribute them,’ knowing that?”McCain: (Twelve-second pause) “Get me Coburn’s thing, ask Weaver(senior adviser) to get me Coburn’s paper that he just gave me in the last couple of days. I’ve never gotten into these issues before.”
Recent surveys found that 79 per cent of adult males detained on property offences tested positive to a drug of some type (excluding tobacco and alcohol)- (Source: Australian Institute of Criminology, 2006)